Cleavage of LRP1 and increase in LRP1-ICD in ischemic brain and excitotoxic neuronal injury
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چکیده
منابع مشابه
LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein.
The trafficking of normal cellular prion protein (PrPC) is believed to control its conversion to the altered conformation (designated PrPSc) associated with prion disease. Although anchored to the membrane by means of glycosylphosphatidylinositol (GPI), PrPC on neurons is rapidly and constitutively endocytosed by means of coated pits, a property dependent upon basic amino acids at its N-terminu...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2020
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.93.0_1-p-048